brian-jens-oliver_LECTURECOSBID investigators have published over 30 articles in peer-reviewed medical journals that collectively have established spreading depolarizations as a new field of clinical investigation. The following selected articles highlight just a few of the key advances of this field in understanding clinical stroke and traumatic brain injury.

See JCBFM 37(5):2017 special issue on Brain Injury Depolarizations


Strong, A.J., et al. Spreading and synchronous depressions of cortical activity in acutely injured human brain. Stroke 33: 2738-2743 (2002).

Fabricius, M., et al. Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex. Brain 129: 778-790 (2006).

Dreier, J.P., et al. Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. Brain 129: 3224-3237 (2006).

Dohmen, C., et al. Spreading depolarizations occur in human ischemic stroke with high incidence. Ann Neurol 63: 720-728 (2008).

Dreier, J.P., et al. Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain. 132: 1866-1881 (2009).

Bosche B, Graf R, Ernestus RI, et al. Recurrent spreading depolarizations after subarachnoid hemorrhage decreases oxygen availability in human cerebral cortex. Ann Neurol. 67(5): 607-617 (2010).

Nakamura H, Strong AJ, Dohmen C, et al. Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions. Brain. 133(Pt 7): 1994-2006 (2010).

Hartings JA, Watanabe T, Bullock MR, et al. Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma. Brain. 134(Pt 5): 1529-1540 (2011).

Hartings, J.A., et al. Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study. Lancet Neurol 10: 1058-1064 (2011).

Drenckhahn C, Winkler MK, Major S, et al. Correlates of spreading depolarization in human scalp electroencephalography. Brain. 135(Pt 3): 853-868 (2012).

Hertle DN, Dreier JP, Woitzik J, et al. Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury. Brain135(Pt 8):2390-8. (2012).

Dreier JP, Major S, Pannek HW, Woitzik J, Scheel M, Wiesenthal D, et al. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain. 135(Pt 1):259-75 (2012).

Woitzik J, Hecht N, Pinczolits A, et al. Propagation of cortical spreading depolarization in the human cortex after malignant stroke. Neurology 80(12): 1095-1102 (2013).

Hartings JA, Wilson JA, Hinzman JM, et al. Spreading depression in continuous electroencephalography of brain trauma. Ann Neurol. 76(5): 681-94 (2014).

Drenckhahn C, Windler C, Major S, Kang EJ, Scheel M, Vajkoczy P, et al. Complications in aneurysmal subarachnoid hemorrhage patients with and without subdural electrode strip for electrocorticography. J Clin Neurophysiol. 33(3): 250-9 (2016).

Hartings JA, Li C, Hinzman JM, Shuttleworth CW, Ernst GL, Dreier JP, Wilson JA, Andaluz N, Foreman B, Carlson AP. Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations. J Cereb Blood Flow Metab. 2016 Jan 1.

Helbok R, Schiefecker AJ, Friberg C, Beer R, Kofler M, Rhomberg P, et al. Spreading depolarizations in patients with spontaneous intracerebral hemorrhage: association with perihematomal edema progression. J Cereb Blood Flow Metab. 2016 Jan 1.

Hinzman JM, Wilson JA, Mazzeo AT, Bullock MR, Hartings JA. Excitotoxicity and Metabolic Crisis Are Associated with Spreading Depolarizations in Severe Traumatic Brain Injury Patients. J Neurotrauma. 33(19): 1775-83 (2016).