The following articles summarize current understanding and progress in the study of spreading depolarizations and their relevance to clinical neurology. They may serve as an introduction to the topic for investigators new to this field. See the JCBFM 37(5):2017 special issue on Brain Injury Depolarizations.

Somjen, G.G. Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiological Reviews 81: 1065-1096 (2001).

Iadecola, C. Bleeding in the brain: Killer waves of depolarization in subarachnoid bleed. Nat Med 15: 1131-1132 (2009).

Dreier, J.P. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 17: 439-447 (2011).

Lauritzen, M., et al. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab 31: 17-35 (2011).

Eikermann-Haerter K, Negro A, Ayata C. Spreading depression and the clinical correlates of migraine. Rev Neurosci. 24(4): 353-363 (2013).

Ayata C, Lauritzen M. Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiological Reviews. 95(3): 953-93 (2015).

Dreier JP, Reiffurth C. The Stroke-Migraine Depolarization Continuum. Neuron. 86(4): 902-22 (2015).

Hartings JA. Spreading depolarization monitoring in neurocritical care of acute brain injury. Current Opinion in Critical Care. 23(2):94-102 (2017).

Consensus Reviews

Hartings JA, Shuttleworth CW, Kirov SA, Ayata C, Hinzman JM, Foreman B, et al. The continuum of spreading depolarizations in acute cortical lesion development: Examining Leao’s legacy. J Cereb Blood Flow Metab. 2016 Jan 1.

Dreier JP, Fabricius M, Ayata C, Sakowitz OW, William Shuttleworth C, Dohmen C, et al. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. J Cereb Blood Flow Metab. 2016 Jan 1.