We are excited that JCBFM has selected the COSBID group for a special issue of the journal. Editors Martin Lauritzen and Ulrich Dirnagl initiated the format of special Clinical Issues to increase representation of clinical and translational research topics in the journal. The inaugural Clinical Issue, published in 2015, will be devoted to the topic of vascular dementia. The next issue will focus on brain injury depolarizations, with contributions in clinical and basic science from COSBID researchers. Publication in 2016 is expected. More information is available at JCBFM.